The following study which came out in the latest Nature issue, boosts the efficiency of producing iPS cells (reprogrammed) from 10% to 100%, and that too by perturbing a single gene "Mbd3 ( a nucleasome remodeller and a core player in deacteylation).
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12587.html
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12587.html
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