The study identifies the mechanism by which constitutive DNA-damage present in human cancer cells drives tumorigenesis. Additionally, it highlights a novel bio marker for stratification of patients for the next generation CHK1 inhibitors, being developed in academia and industry.
http://cancerres.aacrjournals.org/content/early/2013/09/26/0008-5472.CAN-13-1002.full.pdf+html
http://cancerres.aacrjournals.org/content/early/2013/09/26/0008-5472.CAN-13-1002.full.pdf+html
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